Jian Yang, PhD
Professor of Biomedical Engineering
Pennsylvania State University
Multifunctional Citrate Biomaterials and Applications
In recent years, citrate-based biomaterials have become an intense focus of research in the search of new functional biomaterials for solving unmet medical problems. Citric acid, historically known as an intermediate in the Krebs cycle, is a multifunctional, nontoxic, readily available, and inexpensive cornerstone monomer used in the design of citrate-based biomaterials. In addition to the convenient citrate chemistry for the syntheses of a number of versatile polymers that may be elastomeric or mechanically strong and tough, injectable and photocrosslinkable, and/or tissue adhesive, citric acid also presents inherent anti-bacterial and anti-clotting characteristics, which make citrate biomaterials ideal for a number of medical applications. All these features make citrate biomaterials promising and worth further developing. Interestingly, the citrate chemistry endows a great freedom in the design of imaging-enabled biodegradable polymers and small molecules, thus greatly expanding the functions and capabilities of the citrate-based biomaterials. Herein, a methodology for the design and biomedical applications of multifunctional citrate biomaterials with a focus on the imaging enabled materials will be discussed.
Dr. Yang received his PhD in Polymer Chemistry and Physics in 2002 at Institute of Chemistry, The Chinese Academy of Science in Beijing. He is currently a full professor at the Department of Biomedical Engineering, The Pennsylvania State University. Dr. Yang has published 98 peer-reviewed journal articles, 9 issued patents, and 8 book chapters. He was a recipient of NSF CAREER Award (2010) and Outstanding Young Faculty Award of College of Engineering at UTA (2011). Dr. Yang was elected to the Fellow of American Institute of Medical and Biological Engineering (AIMBE) (Class of 2016). Dr. Yang serves as an Associate Editor for the journals “Bioactive Materials” and “Frontiers in Biomaterials” and also serves as a standing member for NIH “Biomaterials and Biointerfaces” study section. Dr. Yang is the founding secretary for (Oversea) Chinese Association for Biomaterials (CAB). He has co-founded a biotechnology company, Aleo BME, Inc. and is also serving on the medical advisory board for Acuitive Technologies, Inc.