James Haorah, Ph.D.
Department of Pharmacology
and Experimental Neuroscience
University of Nebraska Medical Center
The Journey of Hope, Achievements and Beyond. Thanks to Alcohol
My talk will begin with the foundation of my personal research interest in substance use, particularly to understand the underlying molecular, biochemical, and cellular mechanisms of brain injury and neurological diseases. The central idea is that oxidative damage of the blood-brain barrier interface is the cause of immune cell infiltration, perivascular inflammation, neuronal degeneration and progression of neurological diseases. Such neuropathologic progression accelerates the impairment of essential nutrients transport into the brain. Thus, interruption of brain cells energetic communication imbalances the mitochondrial oxidative phosphorylation to promote neurological disorders in chronic substance use and HIV-1 infection.
Future goals include the collaborative research in the area of: a) Prevention of neurovasculature piercing by the sharp edges of cholesterol crystals formation in a unique animal model of stroke, and translational confirmation in alcoholic subjects. b) Interruption of energetic interactions and signal transmission in neuro-glial cells as the basis for oxidative stress, neurological disorders and fast ageing in chronic methamphetamine abuse. c) Oxidative stress and metabolic imbalance as the basis for co-morbid effects of alcohol and HIV-1 infection during HIV/AIDS progression. d) Oxidative damage and inflammation of the neurovascular components in traumatic brain injury by primary blast wave animal model impacting neuropsychiatry disorders. e) Strengthen the effective teaching in the area of Neurobiology, Neuropharmacology, Neuroimmune Pharmacology, and CNS cell communication for graduate and undergraduate courses.
Dr. Haorah received his PhD in 1995 from the Institute of Biophysics at North Eastern Hills University Shillong India, in the area of chemical carcinogens and epidemiology of cancers. He did his postdoct and Research scientist at the University of Nebraska Medical Center from 1995-2002. Then he joined the department of Pharmacology and Experimental Neuroscience at UNMC as Research Instructor (2003-2006), Assistant professor (2007-2010), and associate professor (2011-present). Since 2007, Dr. Haorah has been continuously funded by NIH/NIAAA and actively involved in teaching courses to Medical, Pharmacy, PA and graduate students. I look forward to strengthening the teaching programs and research collaborations in the area of neurological disorders from various interdisciplinary fields.