Sridhar Kannurpatti, Ph.D.
Department of Radiology
RUTGERS-New Jersey Medical School
Physiological impact of mitochondrial calcium homeostasis in the brain
Mitochondrial dysfunction in implicated in numerous neuropathologies where its calcium ion (Ca2+) homeostasis is disrupted. Though cellular mechanisms of Ca2+ integration by mitochondria is well known, its in vivo impact in terms of brain physiological response is not known. This is primarily due to challenges in studying mitochondrial functions in vivo. Results from in vivo approaches through pharmacological modulations of mitochondrial Ca2+ uptake (uniporter system) in the working brain and its impact on neuronal activity and neuroimaging makers will be presented. The relevance of studying mitochondrial Ca2+ homeostatic pathways in intact animal models as potential therapeutic targets in neuropathology will be discussed.
Dr. Sridhar Kannurpatti received his PhD in Biophysics from the National Institute of Mental Health and Neurosciences (NIMHANS) in India. He completed his postdoctoral fellowship at the Biophysics Research Institute, Medical College of Wisconsin in the areas of Functional Magnetic Resonance Imaging (fMRI). He continued in the field of neuroimaging while applying other modalities such as optical imaging to study brain function. He is currently an Assistant Professor of Radiology at RUTGERS-New Jersey Medical School. He has worked on both in vitro and in vivo systems applying various biophysical methods to decipher central nervous system response. His current research on mitochondrial function and its relationship to brain neural and hemodynamic responses has led to strategies.