Vivek A. Kumar
|Dept:||Biomedical Engineering & CBPE|
(Check us out at kumarlab.njit.edu)
Vivek A. Kumar, PhD, assisstant professor in the departments of biomedical engineering and chemical engineeering at New Jersey Institute of Technology, studies and invents the next generation of biomaterials. Dr. Kumar’s work in biomaterials for angiogenesis, inflammation modulation, soft tissue engineering and drug development has been supported over the past decade by grants and fellowships from the National Institute of Health, American Heart Foundation and numerous other private organizations. Vivek’s research interests lie at intersection of biomaterials, drug discovery and clinical translation. The platform technologies his laboratory is inventing are focuss on using this platform of natural/ bio-synthetic materials to address a number of pathologies plaguing American’s today.
Emblematic of this are the milieu of projects that build upon this biomaterials platform:
Regeneration of soft and hard tissue in the oral cavity
(collaboration with Dr. Saul Weiner (Rutgers))
Stimulation of robust angiogenic responses for the treatment of ischemic tissue disease (critical limb ischemia)
Development of composite vascular grafts that mitigate inflammation and promote functional media/ adventitia
Delivery of novel antiangiogenic molecules to mitigate abnormal angiogenesis in diabetic retinopathy
Development of novel pro-/anti-coagulants for management of traumatic/ surgical bleeding, and hypercoagulability
Development of new targets and strategies for enhanced vaccination against HIV
(collaboration with Dr. Abraham Pinter (Rutgers))
Stem cell delivery for treatment myocardial (heart muscle) regeneration post-MI (heart attack), and islet cell transplantation
(collaboration with Dr. Eun Jung Lee (NJIT))
Neural tissue regeneration after traumatic brain injury (TBI) / ischemic stroke / spinal cord injury (collaborations with Dr. James Haorah (NJIT) | Dr. Bonnie Firestein (Rutgers) | Dr. Hilton Kaplan (Rutgers))
Post-doc, Chemistry, Rice University (2012-2016)
Post-doc, Surgery, BIDMC, Harvard Medical School (2011-2012)
Ph.D., Bioengineering, Georgia Institute of Technology | Emory University Hospital, 2006-2011
B.S., Biomedical Engineering, Northwestern University, 2003-2006
Assistant Professor, New Jersey Institute of Technology, Department of Biomedical Engineering, 2016 – present
Start-up entrepreneur, 2015 – present
HONORS AND AWARDS
Ruth L. Kirchstein National Research post-doctoral Fellow, 2013 – 2016
American Heart Association Pre-doctoral Fellowship, 2010 – 2012
Mid Atlantic BioAngels – Winner of start-up pitch competition, 2016
OPEN, NangioTx, Inc – Winner of start-up pitch competition ($10,000), 2015
TMCx | Bioventures, NangioTx, Inc – Winner of start-up pitch competition ($10,000), 2015
Materials Research Society - Symposium Travel Award, 2014
Gordon Research Conference - Biomaterials & Tissue Engineering Outstanding Poster, 2013
Harold B. Gotaas Award - Outstanding Research, Northwestern University, 2006
Undergraduate Research Honors - Research and Academic Accomplishment, Northwestern University, 2006
Top prize in engineering design competition, Northwestern University, 2004
Served as reviewer for:
NSF SBIT/STTR panel Fall - 2016
Materials Research Society
Public Library of Science One
Journal of AIDS and HIV Infections
(Check us out at kumarlab.njit.edu)
Biomedical Translation and Entrepreneurship, Special Topics, TBD.
The focus of this course is to understand the fundamentals behind biomaterials design and biomaterials translation. A focus on materials synthesis, mechanics, and host responses will be followed by developing your idea for clinical translation. We will teach you how to take an idea, refine it scientifically, and develop components of what will ultimately form the basis of a company to take your idea to market. Part 1 will be a discussion of papers in the literature that provide the foundation for translational research at the “bench”, followed by a quiz (2 quizzes in total for part 1). Part 2 will focus on translation of biomaterials with a focus on entrepreneurship. You will learn how to evaluate, critique, and pitch your technology to future investors in your own “startup”. Overall, this course is designed to provide an understanding in the translation of biomedicine – defining on the bench to market paradigm.
(Check us out at kumarlab.njit.edu)
Ongoing Research Support
NJIT Faculty seed grant Kumar(PI) 09/16-06/17
“Development of Cytocompatible, Injectable Hydrogel Matrices for Soft Tissue Repair”.
This seed grant will allow for the development of electro-conductive multidomain peptide scaffolds capable of carrying charge for synchronous cardiomyocyte beating, prior to implantation.
NJIT startup funds Kumar (PI) 08/16-08/19
Completed Research Support
MacDonald Foundation, 15RDM001 Kumar (Co-I) 01/15-01/16
“Multidomain peptides for therapeutic regeneration of myocardial tissue post infarct.”
The goal of this work is to understand and develop proangiogenic strategies for healing of myocardial tissue post-MI. This was in conjunction with Jeffery Hartgerink, PhD and Richard Dixon, PhD.
NIH/NIDCR, F32 DE023696-01A1 Kumar (PI) 09/13-08/16
“Multidomain peptides for inflammation and angiogenic mediated tissue regeneration.”
This work provided the foundation for the multidomain peptides that are being investigated in this proposal. This funding opportunity allow for prolific productivity with over a half dozen publications resulting from funding from this post-doctoral grant with advisor Jeffrey Hartgerink.
AHA (10PRE 3060026) Kumar (PI) 07/10-03/12
“Biomimetic arterial grafts with mesenchymal stem cell based media equivalents”
This pre-doctoral fellowship investigated the development of tissue engineered vascular grafts for small diameter blood vessel tissue engineering and hernia patches. This fellowship aided in over a dozen publications with graduate thesis advisor Elliot Chaikof, MD, PhD.
- Soft tissue regeneration (vascular, muscle, neural)
- Hard tissue engineering (bone)
- Neural engineering and repair (stroke, TBI)
- Coagulants/ anti-coagulants
- Vaccine development
- Drug, stem cell and growth factor delivery (diabetic retinopathy, therapeutic angiogenesis)
- Translational biomedical sciences
(Check us out at kumarlab.njit.edu)
- S. Shi, P. Nguyen, H. Cabral, R. Diez-Barroso, P. Derry, V. Kumar. Development of peptide inhibitors of HIV transmission. Bioactive Materials, DOI: 10.1016/j.bioactmat.2016.09.004.
- V. Kumar, Q. Liu, N. Wickremasinghe, Siyu Shi, T. Cornwright, Y. Deng, A. Azares, A. Jake, N. Agudo, S. Pan, D. Woodside, J. Willerson, R. Dixon and J. Hartgerink. Treatment of hind limb ischemia using angiogenic peptide nanofibers. Biomaterials, 98, 113, 2016
- V. Kumar* and B. Wang. Rational design of fiber forming supramolecular structures. Experimental Biology and Medicine, 241, 899, 2016
- V. Kumar, N. Wickremasinghe, S. Shi, J. Hartgerink. A nanofibrous snake venom based hemostat. ACS Biomaterials Science and Engineering, 1, 12, 1300, 2015
- V. Kumar, B. Wang, S. Shi, I. Li, A. Jalan, B. Sarkar, N. Wickremasinghe and J. Hartgerink. Drug-triggered and crosslinked self-assembling nanofibrous hydrogels. Journal of the American Chemical Society, 137, 14, 4823, 2015
- V. Kumar, N. Taylor, S. Shi, N. Wickremasinghe, R. D’Souza and J. Hartgerink. Self-assembling multidomain peptides modulate immune responses through biphasic release. Biomaterials, 52, 71, 2015
- V. Kumar, N. Taylor, S. Shi, B. Wang, A. Jalan, M. Kang, N. Wickremasinghe and J. Hartgerink. Highly Angiogenic Peptide Nanofibers. ACS Nano, 9, 860, 2015
- V. Kumar, R. Vissapragada, L. Hwang, M. Fusco, C. Ogilvy, A. Thomas. Cerebral AVMs and dural AVFs: Pathology and management. Endovascular Today, 14, 2, 2015
- N. Wickremasinghe, V. Kumar, Siyu Shi and J. Hartgerink. Tuning in vivo response through temporal controlled release from Multi Domain Peptide composite hydrogels. ACS Biomaterials Science and Engineering, 1, 845, 2015
- R. Vissapragada, V. Kumar, O. Merchant, L. Hwang, M. Fusco, C. Ogilvy, A. Thomas. Material Requirements for Therapeutic Embolization of Intracranial Vascular Malformations. Endovascular Today, 14, 4, 2015.
- L. Hwang, V. Kumar, R. Vissapragada, K. Lui, M. Fusco, C. Ogilvy, A. Thomas. Treatment Options for Cerebral AVMs and Dural AVFs Endovascular Today, 14, 3, 2015.
- V. Kumar, N. Taylor, A. Jalan, L. Hwang, B. Wang and J. Hartgerink. A novel synthetic collagen mimic for hemostasis. Biomacromolecules, 15, 4, 1484, 2014
- V. Kumar, A. Martinez, J. Caves, N. Naik, C. Haller and E. Chaikof. Microablation of collagen-based substrates for tissue engineering. Biomedical Materials, 9,1, 1002, 2014
- N. Wickremasinghe, V. Kumar, J. Hartgerink. Two step self-assembly of liposome-multidomain peptide nanofiber hydrogel for time-controlled release. Biomacromolecules, 15, 10, 3587, 2014
- R. Vissapragada, M. Contreras, C. DaSilva, V. Kumar, A. Ochoa, A. Vasudevan, C. Ferran and A. Thomas. Bidirectional crosstalk between periventricular endothelial cells and neural progenitor cells promotes the formation of a neurovascular unit. Cover art. Brain Research, 1561, 8, 2014
- V. Kumar, J. Caves, C. Haller, E. Dai, L. Liu, S. Grainger and E. Chaikof. Mechanically tunable extracellular matrix mimetics for soft tissue engineering. Biomaterials Science, 1, 11, 1193, 2013
- V. Kumar, J. Caves, C. Haller, E. Dai, L. Liu, S. Grainger and E. Chaikof. Acellular Vascular Grafts Generated from Collagen and Elastin Analogues. Acta Biomaterialia, 9, 3, 8067, 2013
- Z. Qu, S. Muthukrishnan, M. Urlam, C. Haller, S. Jordan, V. Kumar, U. Marzec, Y. Elkasabi, J. Lahann, S. Hanson, E. Chaikof. A biologically active surface enzyme assembly that attenuated thrombus formation. Advanced Functional Materials, 21, 24, 4746, 2011
- N. Naik, V. Kumar, E. Chaikof and M. Allen. MEMS-assisted spatially homogeneous endothelialization of a high length-to-depth aspect ratio microvascular network. IEEE Eng Med Bio Soc., 8, 290, 2011
- V. Kumar, L. Brewster, J. Caves, E. Chaikof. Tissue Engineering of blood vessels: current status, requirements and future challenges. Cardiovascular Engineering and Technology, 2, 3, 137, 2011
- J. Caves, W. Cui, J. Wen, V. Kumar, A. Martinez, E. Chaikof. Elastin-like protein matrix reinforced with collagen microfibers for soft tissue repair. Biomaterials, 32, 23, 5371, 2011
- J. Wilson, W. Cui, V. Kozlovskaya, E. Kharlampieva, D. Pan, Z. Qu, V. Krishnamurthy, J. Mets, V. Kumar, J. Wen, Y. Song, V. Tsukruk, and E. Chaikof. Cell Surface Engineering with Polyelectrolyte Multilayer Thin Films. Journal of the American Chemical Society, 133, 18, 7054, 2011
- J. Caves%, V. Kumar%, A. Martinez, J. Kim, C. Ripberger, C. Haller, E. Chaikof. The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts. (% co-first authorship) Biomaterials, 31, 7175, 2010.
- J. Caves, V. Kumar, W. Xu, N. Naik, M. Allen, E. Chaikof. Microcrimped collagen fiber-elastin composites. Advanced Materials 24, 2041, 2010. Research Highlights, Nature Materials 9, 285, 2010
- J. Caves, V. Kumar, J. Wen, W. Cui, A. Martinez, R. Apkarian, J. Coats, K. Berland, E. Chaikof. Fibrillogenesis in continuously spun synthetic collagen fiber. Journal of Biomedical Materials Research Part B. Applied Biomaterials, 93b, 24, 2009
- N. Naik, J. Caves, V. Kumar, E. Chaikof, M. Allen. A template-based fabrication technique for spatially-designed polymer micro/nanofiber composites. Transducers, 21, 1869, 2009
- A. Webb, V. Kumar and G. Ameer. Biodegradable poly(diol citrate) nanocomposite elastomers for soft tissue engineering. Journal of Materials Chemistry, 17, 900, 2007