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Department of Biomedical Engineering

Sahin, Mesut

Contact Info
Title: Associate Professor
Email: mesut.sahin@njit.edu
Office: 617 Fenster Hall
Phone: 973-596-5573
Dept: Biomedical Engineering Department
Webpage: http://web.njit.edu/~sahin

About Dr. Sahin

Dr. Sahin’s primary area of research is Neural Prostheses in the broader field of Neural Engineering.  His PhD dissertation was on a neural prosthesis for obstructive sleep apnea and he owns a patent on close loop control of hypoglossal nerve stimulations on demand.  His research interests moved to the central nervous system during post-doctoral studies at Case Western Reserve University where he conceived the idea of using the neural activity of the descending tracts in the spinal cord as a form of brain-computer interface.  The project was funded by a post-doctoral fellowship from Christopher Reeve Paralysis Foundation and later by The Whitaker Foundation.  This pioneering work, now called spinal-cord computer interface, still continues in Sahin’s laboratory with new directions.  In his first academic post as an assistant professor, Sahin proposed another new concept of floating light activated micro-electrical stimulators (FLAMES) for wireless activation of the central nervous systems.  This original project is currently under development and constitutes one of the major research efforts in Sahin’s laboratory with support from NIH.  For the past few years, his research interest has expanded to include recordings of multi-unit activities from the cerebellum using flexible multi-electrode arrays and from the spinal cord using micro wires.

Education

  • Case Western Reserve University, PhD in Biomedical Engineering 1998
  • Case Western Reserve University, MS in Biomedical Engineering 1993
  • Istanbul Technical University, BS in Electrical Engineering 1986

Professional Experience

 

  • Associate  Professor, Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, Sept. 2009- present

  • Assistant Professor, Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, Sept. 2005- 2009

  • Assistant Professor, Biomedical Engineering, Louisiana Tech University, Ruston, LA, Jan 2001- Sept. 2005
  • Research Associate, Biomedical Engineering, Case Western Reserve University, Cleveland, OH, May 1998- Jan 2001.
  • Research and Development Engineer, TELETAS Inc., Istanbul, Turkey, July 1987-Dec 1990.
  • Research and Development Engineer, TARSAN Inc., Istanbul, Turkey, 1986-July 1987.

 

Professional Activities/Organizations

  • Associate Editor of the IEEE Transactions of Biomedical Circuits and Systems journal
  • Senior Member – The Institute of Electrical and Electronics Engineers (IEEE)
  • Member – IEEE Engineering in Medicine and Biology Society (EMBS)
  • Member – Biomedical Engineering Society
  • Track and Session Chair for IEEE/EMBS and IEEE Neural Engineering Conferences
  • Reviewer for IEEE Transactions on Biomedical Engineering
  • Reviewer for IEEE Transaction on Neural Systems and Rehabilitation Engineering
  • Reviewer for Journal of Neural Engineering

Courses I Teach

INTRO BIOMEDICAL ENGINEERING I
BIOINSTRUMENTATION LABORATORY
RESEARCH & INDEPENDENT STUDY I
RESEARCH & INDPNDNT STUDY II
INDEPENDENT STUDY
INDEPENDENT STUDY II
PRE-DOCTORAL RESEARCH
MASTER'S PROJECT
MASTER'S THESIS
MASTER'S THESIS
DOCTORAL DISSERTATION
DOCTORAL DISSERTATION
DOCTORAL DISSERTATION
DOCTORAL DISSERTATION
DOCTORAL DISSERTATION
DOCT DISSERTATION & RESEARCH

Major Teaching Experience

 

-          Electrical Fundamentals of Biomedical Engineering, BME301H, 2005-2010

-          Biomedical Instrumentation Laboratory, BME 386, New Course, Fall 2008-present

-          Medical Instrumentation, BME 687, 2006-present

-          Digital Signal Processing, BIEN 425, 2002-2005 (at Louisiana Tech University)

-          Neural Engineering, BIEN 557, New Course, 2002-2004 (at Louisiana Tech University)




Research Interests

  • Neural Recording with Microelectrode arrays
  • Neural Prostheses/Neural Interfaces
  • Spinal Cord/Brain-Computer Interface
  • Floating Micro-Stimulators
  • Neural Signal Extraction/ Analysis
  • Spinal Cord Injury (SCI)
  • Obstructive Sleep Apnea (OSA)
  •  Autonomic Control of the Heart Rate

Patents

US Patent # 6,587,725, “Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea”, Dominique Durand, Mesut Sahin, and Musa A. Haxhiu, July 2003.


Selected Publications

 

Book Chapter
Mesut Sahin and Jingtao Huang, “Obstructive Sleep Apnea: Electrical Stimulation Treatment”, Wiley Encyclopedia of BME, Edited by Metin Akay, Wiley Publications, 2006.
 
Peer-Reviewed Journal Papers
 
  • Mesut Sahin and Victor Pikov, “Wireless Micro-stimulators for Neural Prosthetics”, Critical Reviews in BME, (accepted).

  • Abdo, Ammar and Mesut Sahin, “Feasibility of Neural Stimulation with Floating Light Activated Micro-Electrical Stimulators,” Tran. on Biomed. Circuits and Systems (accepted).

  • Abhishek Prasad, and Mesut Sahin, “Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord.” Frontiers in Neuroscience, vol. 4, article 21, pp. 1-7, June 2010.

  • Mesut Sahin, S.S. Ur-Rahman, “Finite Element Analysis of a Floating Micro-Stimulator,” IEEE Tran. on Neural Systems and Rehab., July 2007.
  • Mesut Sahin and Yanmei Tie, “Non-Rectangular Waveforms for neural stimulation with practical electrodes,” J. of Neural Eng., vol 4, pp. 227-233, 2007.
  • Abhishek Prasad and Mesut Sahin, “Extraction of motor activity from the cervical spinal cord of behaving rats,” J. Neural Eng., vol. 3, pp. 287-292, 2006.
  • Yanmei Tie, Mesut Sahin, Nappinnai Sundararajan, “Organization in the descending tracts of the dorsolateral funiculus in the cat,” Brain Res., vol. 1117, pp.61-68, 2006.
  • Yanmei Tie and M. Sahin, “Separation of spinal cord motor signals using the FastICA method,“ J. Neural Eng., vol. 2, 2005, pp. 90-96.
  • Jingtao Huang and M. Sahin, “Dilation of the Oropharynx via Selective Stimulation of the Hypoglossal Nerve”, J. of Neural Eng., No 2, 2005, pp. 73-80.
  •  Mesut Sahin, “Information capacity of the corticospinal tract recordings as a neural interface,” Ann. of Biomed. Eng. Vol. 32, No. 6, pp. 823-830, June 2004.
  • Mesut Sahin, Dominique M. Durand, and Musa A. Haxhiu, "Closed-loop stimulations of hypoglossal nerve using its spontaneous activity as the feedback signal", IEEE Tran. on Biomed. Eng., Vol. 47, No. 7, pp. 919-925, July, 2000.
  • Mesut Sahin, Dominique M. Durand, and Musa A. Haxhiu, "Chronic recordings of hypoglossal nerve in a dog model of upper airway obstruction" J. Apply. Physiol. Vol. 87, No. 6, pp. 2197-2206, 1999.

Conference Papers

  • Groth, J., and M. Sahin, “Signal Characteristics of Cerebellar Activity Recorded with Micro-Electrode Arrays,” Annual International Conf. of IEEE/EMBS, Minneapolis, MN, Sept 2009.
  • Ammar Abdo, Vianney Jayasinha, Phil Spuhler, M. Selim Unlu and Mesut Sahin, “In Vitro Testing of Floating Light Activated Micro-Electrical Stimulators,” Annual International Conf. of IEEE/EMBS, Minneapolis, MN, Sept 2009.
  • Abhishek Prasad*, and Mesut Sahin, “A Spinal Cord Computer Interface Based on Local Field Potentials during Reach-and-Grasp Task” Neural Engineering Conference, Cleveland, Ohio, June 2008.

 

Proceedings and Presentations

 

  • Mesut Sahin, “Brain-Computer Interfacing: Too Many Choices of Brain Sites for Recording Volitional Activity” International Brain Mapping & Intraoperative Surgical Planning Society, UCLA Campus, Los Angeles, CA, August 2008 (Invited Presentation).
  • Jonathan Groth, Nicholas Sachs, and Mesut Sahin, “Surface Recordings from the Rat Cerebellum Using a Multi-electrode Array,” Neural Engineering Conference, Cleveland, Ohio, June 2008.
  • Ammar Abdo, and Mesut Sahin, “Floating Light Activated Micro-Electrical Stimulators,” Neural Engineering Conference, Cleveland, Ohio, June 2008.
  • Mesut Sahin, “Optimal Pulse Widths for Effective Use of the Electrode Surface Area,” The 3rd International IEEE/EMBS Conference on Neural Engineering, Hawaii, May 2007. 
  • Mesut Sahin, Mustafa Patan, Arthur Che-An Wu, and M. Selim Unlu, “Floating Light Activated Micro-Electrical Stimulators (FLAMES): Modeling and In Vivo Testing,” 37th Neural Interface Workshop, Bethesda, MD, Sept 2006.
  • Mustafa Patan, Tosha Shah, and M. Sahin, “Charge Injection Capacity of TiN Electrodes for an Extended Voltage Range,” Proc. of 28th Annual International Conf. of IEEE/EMBS, New York, 2006.
  • Marcia A. Pool, and M. Sahin, “Extraction of Cardiac Parameters from Vagus Nerve Recordings,” 37th Neural Interface Workshop, Bethesda, MD, Sept 2006.
  • Mesut Sahin, Kimberlyn Gray, Sunil A. Kavuri, Steven Menn, and M. Selim Unlu, “Floating Light Activated Micro-Electrical Simulators”, Oral Presentation at Neural Interface Workshop organized by National Institute of Health, Bethesda, MD, Sept 2005 (Invited Presentation).
  • Yanmei Tie, M. Sahin, N. Sundararajan, and A. Rane, “Organization of the Fibers in the Dorsolateral Funiculus of the Cervical Spinal Cord in the Cat”, Proc. of 26th Annual International Conf. of IEEE/EMBS, San Francisco, September, 2004.
  • Kimberlyn M. Gray, H.K. Innamuri, A. Tayebi, and M. Sahin, “Voltage field generated by a single photodiode in a volume conductor: Simulation and measurements”, 25th Annual International Conf. of IEEE/EMBS, Cancun, Mexico, September, 2003.
  • Jingtao Huang, M. Sahin, and D. Durand, “Imaging of Upper Airways During Hypoglossal Nerve Stimulation,” First Int. Conf. on Neural Eng., Italy, March, 2003.
  • Mesut Sahin, “Noise tolerance as a measure of channel discrimination for multi-channel neural interfaces”, 23th Annual International Conference of the IEEE Eng. in Med. and Biol. Soc., Istanbul, Turkey, Oct 25-28,2001.
  • Mesut Sahin and Dominique M. Durand, "Hypoglossal Nerve Recordings in Sleeping Dogs", Biomedical Engineering Society 1998 Annual Fall Meeting, Cleveland, OH, 1998
  • Mesut Sahin and Dominique M. Durand, "Selective recordings with a multi-contact nerve cuff electrode", 18th Annual International Conference of the IEEE Eng. in Med. and Biol. Soc., Amsterdam, Netherlands, 1996.
  • Mesut Sahin, Musa A. Haxhiu, and Dominique M. Durand, "The spiral nerve cuff electrode for acute recordings of hypoglossal nerve activity", American Thoracic Society (ATS) International Conference, May 21-24, Seattle, WA, 1995
  • Mesut Sahin and David L. Wilson, "Monte Carlo Simulations of Image Stacking", In Proceedings of SPIE Image Processing, Vol. 1898, pp. 825-832, San Diego, CA, 1993.