Dr. Sahin’s interests are in the field of Neural Prosthetics within a broader area of Neural Engineering. The long term objective is to develop devices that can help disabled individuals due to neural injuries such as spinal cord injury, traumatic brain injury, ALS, and stroke. Most projects in Dr. Sahin’s Neural Interface Laboratory (690 Fenster) involve pre-clinical testing of new electrodes, signal processing techniques, and devices. Neural signals from the spinal cord, brain cortex, or the cerebellum are collected while the subjects are performing a task that they are trained for. An important part of neural prosthetic research is to analyze and interpret the neural signals acquired from an area of the nervous system in their natural form in order to understand the neural circuits that generate them. Thus, there is a significant basic science component in Neural Prosthetics research that needs to be completed before an engineering idea can be introduced as a possible treatment for a particular neurological disorder.
A specific research objective in Neural Interface Laboratory is to bridge the site of injury with a neural prosthetic device in patients with spinal cord injury. This requires both extracting volitional information generated by the subject by recording neural signals from a site in the central nervous system, and using these volitional control signals to activate the distal part of the spinal cord that is still healthy using small electric currents in order to recover some of the motor function that is lost due to injury.
PhD in Biomedical Engineering, Case Western Reserve University
MS in Biomedical Engineering, Case Western Reserve University
BS in Electrical Engineering, Istanbul Technical University
Associate Professor, Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, September 2009- present
Assistant Professor, Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, September 2005- 2009
Assistant Professor, Biomedical Engineering, Louisiana Tech University, Ruston, LA, January 2001- September 2005
Associate Editor of the IEEE Transactions of Biomedical Circuits and Systems journal
Senior Member – The Institute of Electrical and Electronics Engineers (IEEE)
Member – IEEE Engineering in Medicine and Biology Society (EMBS)
Member – Biomedical Engineering Society
Track and Session Chair for IEEE/EMBS and IEEE Neural Engineering Conferences
Reviewer for IEEE Transactions on Biomedical Engineering
Reviewer for IEEE Transaction on Neural Systems and Rehabilitation Engineering
US Patent # 6,587,725, “Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea”, Dominique Durand, Mesut Sahin, and Musa A. Haxhiu, July 2003.
System and Method for Neural Stimulation via Optically Activated Floating Micro-Devices, NonProvisional Patent Application No. 13/871,654 was filed with the USPTO on 4/27/2013, Ammar Abdo, Mesut Sahin, David Freedman, and Selim Unlu.
Jonathan Groth, and Mesut Sahin, “High Frequency Synchrony in the Cerebellar Cortex during Goal Directed Movements,” Frontiers in Neuroscience.
Ali Ersen, Stella Elkabes, Mesut Sahin, “Chronic Tissue Response to Unthetered Microelectrodes in Rat Spinal Cord and Brain,” J. Neural Eng., vol. 12(1), Jan 2015.
Gokhan Ordek, Archana Proddutur, Vijayalakshmi Santhakumar, Bryan J. Pfister and Mesut Sahin,“ Monitoring of Cerebellar Evoked Potentials with Micro ECoG Following Fluid Percussion Injury,” Frontiers in Neuroscience, October 2014.
Yi Guo, Sahin Mesut, Richard A. Foulds, and Sergei Adamovich, “Corticospinal Signals Recorded with MEAs can Predict the Volitional Forearm Forces in Rats,” Frontiers in Neurosience: Neuroprosthetics, 8(62), 2014.
Huseyin Guruler, Mesut Sahin, and Abdullah Ferikoglu, “Feature selection on single-lead ECG for obstructive sleep apnea diagnosis,“ Turkish Journal of Electrical Engineering & Computer Sciences, vol. 22, p. 465-478, 2014.
Seymour EÇ, Freedman DS, Gökkavas M, Özbay E, Sahin M and Ünlü MS, Improved Selectivity From a Wavelength Addressable Device for Wireless Stimulation of Neural Tissue. Front. Neuroeng. 7:5, 2014.
Ali Ersen, Ammar Abdo, Mesut Sahin, “Temperature elevation profile inside the rat brain induced by a laser beam,” J. Biomed. Opt. 19 (1), 015009 (January 27, 2014).
David Freedman, Mesut Sahin, and Bruce Towe,: Wireless Microstimulators. In: Jaeger D., Jung R. (Ed.) Encyclopedia of Computational Neuroscience: Springer-Verlag Berlin Heidelberg, 2013.
Ammar Abdo, Ali Ersen, and Mesut Sahin, “Near-infrared light penetration profile in the rodent brain,” J. Biomed. Opt. vol. 18 (7), 075001 (July 05, 2013).
Gokhan Ordek, Jonathan Groth, Mesut Sahin, “Effect of Anesthesia on Spontaneous and Evoked Activity of the Cerebellar Cortex”, J. of Neurophysiol., vol. 109: 1435–1443, 2013.
Abhishek Prasad and Mesut Sahin, “Can volition be extracted from the spinal cord,” Journal of NeuroEngineering and Rehabilitation, vol 9:41, 2012.
Abdo, Ammar and Mesut Sahin, “Floating light-activated micro electrical stimulators tested in the rat spinal cord,” J. Neural Eng. vol. 8, 2011.
Abdo, Ammar and Mesut Sahin, “Feasibility of Neural Stimulation With Floating-Light-Activated Microelectrical Stimulators”, IEEE Tran. Biomed. Circuits and Systems. vol. 5(2), pp. 179-188, Apr 2011.
Sahin, Mesut and Victor Pikov, Wireless Micro-Stimulators for Neural Prosthetics, Critical Reviews in BME, vol. 39(1), pp. 63-77, 2011.
Abhishek Prasad, and Mesut Sahin, “Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord.” Frontiers in Neuroscience, vol. 4, article 21, pp. 1-7, June 2010.