Mohammed Abdul Muneer Peringady

Contact Info

Title: Assistant Research Professor
Email: mohammed.abdul.muneer.peringady@njit.edu
Office: 102 chen
Phone: 973-596-6599
Dept: Biomedical engineering
About: 

About



Mohammed Abdul Muneer, PhD, Assistant Research Professor of Biomedical Engineering Department has various experiences in the field of Neuroscience Research including cellular and molecular mechanisms of traumatic brain injury (TBI), spinal cord injury and optic nerve injury, neurovascular pharmacology of drug of abuse, and neural stem cell research. His current research focuses on understanding the underlying mechanisms of TBI mediated neurovascular inflammation and neurodegeneration that leads to neurological complications and to develop effective therapeutic strategies to enhance recovery from these neurological disorders. He uses in vivo models of TBI such as blast model and fluid percussion model and in vitro stretch injury model to study the mechanisms and therapeutic strategies in brain injury.

 

Education

 

Doctor of Philosophy: Molecular Genetics, Cochin University of Science and Technology, Cochin, India, 2005.
Master of Science: Biotechnology, Cochin University of Science and Technology, Cochin, India, 1998.
Bachelor of Science: Zoology, University of Calicut, Calicut, India, 1995.

Professional Experience

 

2014-                  Assistant Research Professor, Dept. of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ.
2013-2014           Postdoctoral Research Associate, NJ Neuroscience Institute, JFK Medical Center, Edison NJ.
2013-2013           Postdoctoral Research Associate and Lab Manager: Center for Neural Repair and Rehabilitation, Temple University School of Medicine, Philadelphia, PA.
2009-2013           Postdoctoral or Senior Research Associate: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE.
2007-2008           Assistant Professor and Head, Department of Bioinformatics, Mar Athanasios College for Advanced Studies, Thiruvalla, Kerala, India.
2005-2007           Senior officer-Molecular Genetics: National Prawn Co. Al-Lith, Saudi Arabia.

Honors and Professional Activities

 

2004                 Best oral presentation award in the International Conference on Biotechnology and Neuroscience, Society for Biotechnologists, India.
2007-2008         Examination board member for MSc Bioinformatics, Mahatma Gandhi University, Kerala.
2011-present     Editorial Board Member, Journal of Biological Research (Hong Kong).
2013-present     Editorial Board Member, Int. Journal of Medicine and Medical Sciences.
2014-present     Review Editor, Frontiers in Genetics.
2007-present     Member, Society for Biotechnologists of India.
1998-2000         Member, Association of Microbiologists of India.
2009-2013         Member, Research Society on Alcoholism, USA.
2013                 Member, Society for Neuroscience, USA.
2010-present     Peer Reviewer for
                        -Molecular Biology Reports, Journal of Clinical Pharmacology, National Academy Science Letters, Molecular Biotechnology, Gene, Metagene, Proceedings of the National Academy of Sciences-India: Biological Science, African Journal of Biotechnology, Electronic Journal of Biotechnology, Journal of Forestry Research, International Journal of Plant Physiology and Biochemistry.
Research: 

Research Interests

 

Dr. Muneer focuses on understanding the molecular mechanisms behind the constraints in neuronal regeneration after traumatic brain injury and to develop possible therapeutic interventions. He is also highly interested in exploring inter/intracellular signaling pathways and various regulatory factors of neuronal growth in brain injury. Another emphasis of the studies is to unravel the signaling mechanisms of neurodegeneration in central nervous system (CNS) after injuries. The final goal of the study is to develop successful therapeutic strategies for improving recovery from CNS injuries. To achieve these goals, Dr. Muneer employs various in vitro and in vivo research approaches, including blocking of repulsive signaling pathways using pharmacological methods, virus vector mediated gene transfer to the brain, axonal stretch growth cultures, survival animal surgeries etc. His research interests include
  • Neurovascular dysfunction in blast wave and fluid percussion models of traumatic brain injury.
  • Axonal stretch injury and neuroprotection.
  • Blast wave and fluid percussion models of brain injury and neurodegeneration.
  • Mechanisms of spinal cord injury and axonal regeneration.
  • Virus vector mediated gene therapy for brain injury related disorders.
Publications: 

Publications

 Selected  Peer Reviewed Publications

  1. Abdul-Muneer PM*, Chandra N, Haorah J* (2014). Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of secondary mild traumatic brain injury. Molecular Neurobiology, doi.org/10.1007/s12035-014-8752-3. Review manuscript. *Corresponding authors.
  2. Otake Y, Park D, Abdul-Muneer PM, Li H, Xu B, Sharma K, Smith GM, Selzer ME and Li S (2014). The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury. Biomaterials, 35(16):4610-4626.
  3. Li H, Park D, Abdul-Muneer PM, Xu B, Wang H, Xing B, Wu D and Li S (2013). PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience; 253:89-99. 
  4. Abdul-Muneer PM, Schueltz H, Wang F, Skotak M, Jones J, Gorantla S, Zimmerman MC, Chandra N and Haorah J (2013). Induction of Oxidative and Nitrosative damage leads to Cerebrovascular Inflammation in Animal Model of Mild Traumatic Brain Injury Induced by Primary Blast. Free Radical Biology and Medicine; 60: 282–291.
  5. Abdul-Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2012). The Mechanisms of Cerebral Vascular Dysfunction and Neuroinflammation by MMP-mediated Degradation of VEGFR-2 in Alcohol Ingestion. Arteriosclerosis, Thrombosis and Vascular Biology; 32: 1167-1177.
  6. Abdul-Muneer PM*, Alikunju S*, Szlachetka AM, and Haorah J (2011). Methamphetamine Inhibits Glucose Uptake by Human Astrocytes and Neurons: Stabilization by Acetyl-L-carnitine. PLoS ONE, 6(4):e19258. *Joint first authors.
  7. Abdul-Muneer PM, Alikunju S, Szlachetka AM, Murrin CL, and Haorah J (2011). Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction. Molecular Neurodegeneration, 6:23. Highly accessed.
  8. Abdul-Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2011). Inhibitory effects of alcohol on glucose transport across the blood–brain barrier leads to neurodegeneration: preventive role of acetyl-L-carnitine. Psychopharmacology. 214(3): 707-718.
  9. Alikunju S*, Abdul-Muneer PM*, Zhang Y, Szlachetka AM, and Haorah J (2011). The inflammatory footprints of alcohol-induced oxidative damage in neurovascular components. Brain Behavior and Immunity, 25 Suppl 1:S129-36. *Joint first authors.
  10. Abdul-Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2011). Ethanol impairs glucose uptake by human astrocytes and neurons: protective effects of acetyl-L-carnitine. Int J Physiol Pathophysiol Pharmacol. 2011; 3(1): 48-56.
  11. Rump TJ, Abdul-Muneer PM, Szlachetka AM, Lamb A, Haorei C, Alikunju S, Xiong H, Keblesh J, Liu J, Zimmerman MC, Jones J, and Haorah J (2010). Acetyl-L-carnitine Protects Neuronal Function from Alcohol-induced Oxidative Damage in the Brain. Free Radical Biology and Medicine, 49(10): 1494-1504.
  12. Floreani NA, Rump TJ, Abdul-Muneer PM, Alikunju S, Morsey BA, Brodie MR, Persidsky Y and Haorah J (2010). Alcohol-Induced Interactive Phosphorylation of Src and Toll-like Receptor Regulates the Secretion of Inflammatory Mediators by Human Astrocytes. Journal of Neuroimmune pharmacology, 5(4): 533-545.
  13. Abdul-Muneer PM* (2014). Application of microsatellite markers in Conservation Genetics and Fisheries management: Recent advances in population genetic structure and conservation strategies. Genetics Research International, Article ID 691759, 11 pages. Review manuscript.*Corresponding author.
  14. Musammilu KK, Abdul-Muneer PM*, Gopalakrishnan A, Basheer VS, Gupta H, Lal KK, Mohindra V, and Ponniah AG (2014). Identification and characterization of microsatellite markers for population genetic structure in endemic red tailed barb, Gonoprokterus curmuca. Molecular Biology Reports, 41(5):3051-62. *Corresponding author.
  15. Abdul-Muneer PM*, Gopalakrishnan A, Musammilu KK, Basheer VS, Mohindra V, Lal KK, Padmakumar KG and Ponniah AG (2012). Comparative assessment of genetic variability in the populations of endemic and endangered yellow catfish, Horabagrus brachysoma (Hoarabagridae) based on allozymes, RAPD and microsatellite markers. Biochemical Genetics, 50(3-4):192-212. *Corresponding author.
  16. Abdul-Muneer PM*, Gopalakrishnan A, Sivanandan R, Basheer VS, and Ponniah AG (2011). Genetic variation and phylogenetic relationships between two species of yellow catfish, Horabagrus brachysoma and H. nigricollaris using RAPD and microsatellite markers. Molecular Biology Reports, 38 (4): 2225-2232. *Corresponding author. 
  17. Abdul-Muneer PM*, Sivanandan R, Gopalakrishnan A, Basheer VS, Musammilu KK, and Ponniah AG (2011). Identification and characterization of RAPD and microsatellite markers for genetic variation analysis in critically endangered yellow catfish, Horabagrus nigricollaris. Biochemical Genetics, 49(1): 83-95. *Corresponding author.
  18. Sen S, Skaria R and Abdul-Muneer PM* (2010). Genetic Diversity Analysis in Piper Species (Piperaceae) Using RAPD Markers. Molecular Biotechnology, 46(1): 72-79. *Corresponding author.
  19. Abdul-Muneer PM*, Gopalakrishnan A, Musammilu KK, Lal KK, Mohindra V, Basheer VS and Lakra WS (2009). Genetic variation and population structure of endemic yellow catfish, Horabagrus brachysoma (Bagridae) among three populations of Western Ghat region using microsatellite and RAPD markers. Molecular Biology Reports; 36: 1771-1791. *Corresponding author.
  20. Abdul-Muneer PM*, Gopalakrishnan A, Basheer VS and Lakra WS (2008). Identification of RAPD markers in endemic yellow catfish, Horabagrus brachysoma (Gunther, 1864). Asian Fisheries Science, 21, 293-304. *Corresponding author.
  21. Abdul-Muneer PM*, Gopalakrishnan A, Lal KK, and Mohindra V. (2007). Population genetic structure of endemic and endangered yellow catfish, Horabagrus brachysoma using allozyme markers. Biochemical Genetics, 45 (9-10), 637-645. *Corresponding author.
  22. Gopalakrishnan A, Abdul Muneer PM, Lal KK, Mohindra V, Kapoor D and Ponniah AG (2006). Primers from the orders Siluriform and Osteoglossiform detect polymorphic microsatellite loci in sun-catfish, Horabagrus brachysoma. Journal of Applied Ichthyology, 22: 456-458.

 

Selected Abstracts/Papers in Conference/Symposium Proceedings

  1. Abdul Muneer PM, Li H, Ohtake Y, Park P, Longo F, Li S (2013). Role of LAR phosphatase in restricting axon regeneration after spinal cord injury. Abstracts of Annual Scientific Meeting of Society for Neuroscience held at San Diego, CA during Nov 9-13, 2013. 
  2. Skotak M, Abdul Muneer PM, Schueltz H, Wang F, Chandra N and Haorah J (2013). Primary blast induced oxidative and nitrosative Stress causes cerebrovascular inflammation in animal model of mild traumatic Brain injury. Abstracts of the 31th Annual National Neurotrauma Symposium, Auf 4-7, 2013, Nashville, Tenesse. Special Issue: Journal of Neurotrauma 30:A-1–A-183.
  3. Haorah J, Abdul Muneer PM, Alikunju S and Szlachetka AM (2013). The Mechanisms of Cerebral Vascular Dysfunction and Neuroinflammation by MMP-mediated Degradation of VEGFR-2 in Alcohol Ingestion. Abstracts of the 36th Annual Scientific Meeting of the Research Society on Alcoholism JUNE 22-26, 2013, Orlando, Florida. Special Issue: Alcoholism: Clinical and Experimental Research, 37 (S2): 199A.
  4. Haorah J, Abdul Muneer PM and Szlachetka AM (2013). Mechanisms of Cerebral Hemorrhagic Lesions in Drug Abuse Neuroaids. Abstracts of the 19th Annual Scientific Meeting of the Society for Neuroimmune Pharmacology, April 2-7, 2013, Puerto Rico. Special Issue: J Neuroimmune Pharmacol (2013) 8: 478.
  5. Abdul Muneer PM, Schueltz H, Alikunju S, Szlachetka AM, and Haorah J (2012). Mechanisms of alcohol-induced thiamine deficiency in brain pathogenesis: therapeutic role of acetyl-L-carnitine. Abstracts of the 35th Annual Scientific Meeting of the Research Society on Alcoholism JUNE 23-27, 2012, San Francisco, California. Special Issue: Alcoholism: Clinical and Experimental Research, 35 (S1): 122A.
  6. Haorah Jand Abdul Muneer PM (2012). Oxidative damage, cholesterol accumulation and immune cell infiltration in animal model of stroke. Abstracts of the 35th Annual Scientific Meeting of the Research Society on Alcoholism; June 23-27, 2012, San Francisco, California. Special Issue: Alcoholism: Clinical and Experimental Research, 35 (S1): 348A.
  7. Haorah J, Schueltz H, Abdul Muneer PM and Szlachetka AM (2012). Oxidative Injury and Bio-fuel Imbalance as Unifying Mechanisms for Neurological Disorders in Alcohol and Neuroaids. Abstracts of the 18th Annual Scientific Conference on Neuroimmune Pharamcology, April 24-28, 2012, Honolulu, HI, USA. Special Issue: Journal of Neuroimmune Pharmacology, 7 (S1): S5-S81.
  8. Abdul Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2012). Blood-brain barrier dysfunction and Neuroinflammation by MMP-mediated Degradation of VEGFR-2 in Alcohol Abuse. International symposium on advances in Biological Sciences, March 15-17, 2012, Kannur, Kerala, India.
  9. Abdul Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2011). Alcohol-Induced Activation of Matrix Metalloproteinases And Reduction of VEGRF-2 Protein Leads to Blood-Brain Barrier Dysfunction. Abstracts of the 34th Annual Scientific Meeting of the Research Society on Alcoholism June 25-29, 2011, Atlanta, Georgia. Special Issue: Alcoholism: Clinical and Experimental Research, 35 (S1): 239A.
  10. Haorah J, Abdul Muneer PM, Alikunju S, and Szlachetka AM (2011). NLRP3 inflammasome signaling in alcohol-induced animal model of Atherosclerotic stroke. Abstracts of the 34th Annual Scientific Meeting of the Research Society on Alcoholism June 25-29, 2011, Atlanta, Georgia. Special Issue: Alcoholism: Clinical and Experimental Research. 34 (S1): 304A.
  11. Haorah J, Abdul Muneer PM, Alikunju S, and Szlachetka AM (2011). Mechanisms of BBB damage and hemorrhagic stroke in chronic methamphetamine abuse. Abstracts of the 17th Annual Scientific Conference on Neuroimmune Pharamcology, April 5-10, 2011, Clearwater Beach, Florida. Special Issue: Journal of Neuroimmune Pharmacology, 6 (S1): S49-S50.
  12. Abdul Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2010). Alcohol consumption disrupts glucose transport across blood brain barrier and glucose utilization in the brain. Abstracts of the 33rd Annual Scientific Meeting of the Research Society on Alcoholism JUNE 26-30, 2010, San Antonio, Texas. Special Issue: Alcoholism: Clinical and Experimental Research, 34 (S2): 9A–10A.
  13. Sen S, Skaria R and Abdul Muneer PM (2008). Analysis of genetic diversity and phylogenetic relationships among eight eight species of Piper (Piperaceae) using molecular markers. Poster presented in international symposium held at Center for Cellular and Molecular Biology (CCMB), Hyderabad on ‘Nuclear architecture and Chromatin Dynamics’, during Nov 26-29, 2008.
  14. Skaria R, Sen S and Abdul Muneer PM (2008). RAPD analysis of genetic variability among eight varieties of rice (Oryza sativa L.) in Kerala region. Poster presented in international symposium held at Center for Cellular and Molecular Biology (CCMB), Hyderabad on ‘Nuclear architecture and Chromatin Dynamics’, during Nov 26-29, 2008.
  15. Abdul Muneer PM, Gopalakrishnan A, Musammilu KK, Lal KK, Mohindra V and Kapoor D (2004). Detection of genetic variation in the natural populations of endemic yellow catfish, Horabagrus brachysoma using molecular markers. Paper presented (oral) by first author in International Conference on Biotechnology and Neuroscience during 29-31 Dec. 2004. Awarded best presentation for this paper.
  16. Mallia JV, Thomas PC, Muthiah P and Abdul Muneer PM (2004).Application of allozymes as genetic marker in triploid Crassostrea madrasensis. Proceedings in International Conference on Biotechnology and Neuroscience. Pp 274-278.
  17. Chandrasekharan M, Abdul Muneer PM, Appukuttan PC, and Nair KB (1998). “Screening of polyphosphate (polyP) accumulating bacteria from marine environments”. Paper presented (poster by second author) in the National symposium organized by the Association of Microbiologists of India at Mangalore during Dec. 5-7, 1998.

Selected Presentations in Conferences/Symposia

  1. Mechanisms of alcohol-induced thiamine deficiency in brain pathogenesis: therapeutic role of acetyl-L-carnitine. Poster presented in 35th Annual Scientific Meeting of the Research Society on Alcoholism JUNE 23-27, 2012, San Francisco, California.
  2. Blood-brain barrier Dysfunction and Neuroinflammation by MMP-mediated Degradation of VEGFR-2 in Alcohol Abuse. International symposium on advances in Biological Sciences, March 15-17, 2012, Kannur, Kerala, India.
  3. Alcohol-Induced Activation of Matrix Metalloproteinases And Reduction of VEGRF-2 Protein Leads to Blood-Brain Barrier Dysfunction. Poster presented in 34th Annual Scientific Meeting of the Research Society on Alcoholism JUNE 25-29, 2011, Atlanta, Georgia.
  4. Alcohol-induced oxidative stress in neurovascular components. Poster presented in Midland Society for Neuroscience conference held at Boys Town Hospital, Omaha, Nebraska on Dec 6, 2010.
  5. Alcohol consumption disrupts glucose transport across blood brain barrier and glucose utilization in the brain. Poster presented in 33rd Annual Scientific Meeting of the Research Society on Alcoholism JUNE 26-30, 2010, San Antonio, Texas.
  6. Methamphetamine inhibits glucose transport across blood-brain barrier. Midland Society for Neuroscience conference held at Boys Town Hospital, Omaha, Nebraska on Dec, 2009.
  7. Analysis of genetic diversity and phylogenetic relationships among eight species of Piper (Piperaceae) using molecular markers. International symposium held at Center for Cellular and Molecular Biology (CCMB), Hyderabad on ‘Nuclear architecture and Chromatin Dynamics’, during Nov 26-29, 2008.
  8. RAPD analysis of genetic variability among eight varieties of rice (Oryza sativa L.) in Kerala region. International symposium held at Center for Cellular and Molecular Biology (CCMB), Hyderabad on ‘Nuclear architecture and Chromatin Dynamics’, during Nov 26-29, 2008.
  9. Detection of genetic variation in the natural populations of endemic yellow catfish, Horabagrus brachysoma using molecular markers. International Conference on Biotechnology and Neuroscience during 29-31 Dec. 2004. Awarded the best presentation.
  10. Screening of polyphosphate (polyP) accumulating bacteria from marine environments. Poster presented in National symposium organized by the Association of Microbiologists of India at Mangalore during Dec. 5-7, 1998.

Invited Seminar

Blood-brain barrier damage and neurovascular inflammation associated with substance of abuse” at Biosciences and Bioengineering Department, Indian Institute of Technology, Bombay on 29th September, 2011.