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Department of Biomedical Engineering

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About Dr. Kristol

Reactions of amines with chlorocarbons; steric effects in organic reactions; molecular modeling.

Current projects include: synthetic organic reactions involving amines and compounds containing only carbon and chlorine. Products include such acyclic functional groups as nitriles, amidinium salts and amides. Heterocyclic products include pyrazoles. Syntheses of pyrimidines are investigated. Characterization of products from the blood of diabetic patients: Compounds are isolated by extraction and chromatography which contain glucose residues attached to lipid molecules. These compounds, which are steroid derivatives, may be markers for correlating the debilitating effects of diabetes with the chemistry of the blood.

The work is performed in conjunction with the Veterans Administration Medical Center. Molecular modeling of histamine receptors is also being conducted.

Education

  • New York University, PhD 1969
  • New York University, MS 1966
  • Brooklyn College, BS 1958

Courses I Teach

Not teaching any courses this semester

Research Interests

 

  • Reactions of Amines with Chlorocarbons
  • Modeling of Cardiovascular Dynamics 
  • Mathematical Modeling of Acetylcholineesterase
  • Steric Effects in Organic Reactions

 


Publications

 

  •  "Redefining Ion Pairs in Proteins", Proteins: Structure, Function and Genetics (in press), C.Linaras, D.Kristol and A.Ritter.
  • "Effect of Electrostatic Interactions in Recognition of Acetylcholine by Acetylcholinesterase", J. Molecular Structure Theochem, J. Molecular Structure Theochem 425, 81 (1998) C. Linaras, K. Singh, D.Kristol and A. Ritter.
  • "Computer Simulation of Cerebrovascular Circulation and Assessment of Intracranial Hemodynamics During Induction of Anesthesia", J.Clinical Monitoring 12, 1-16 (1996), A. Bekker, S. Wolk, H. Turndorf, D. Kristol and A. Ritter.
  • "Identification of a Pharmacophore for Nucleoside Analog Inhibitors Directed at HIV-1 Reverse Transcriptase", J.Molecular Recognition 7, 211-214 (1994), M.A. Fisher, P.N.S. Yadav, J. Yadav, D. Kristol, E. Arnold and M.J. Modak.
  • "Cyclodextrin Inclusion Compounds: Studies of the Variation in the Size of the Acyclic Guests," J.Am.Chem.Soc. 111, 6765-6772 (1989), M.R.Eftink, M.L.Andy, K.Bystrom, H.D.Perlmutter and D.S.Kristol.
  • "Development of a Dentin Bonding Agent: Correlation of Bond Strength to Microleakage," Innovation and Technology in Biology and Medicine 10, 347-356 (1989), S.Odak, D.Kristol, D.Blackmore and J.Stackhouse.
  • "Effect of Substrate Condition and Substituted Phenols and Methacrylates on Toluene Diisocyanate/Dentin Bond Strengths," J. Biomed. Materials Res. 23, 81-90 (1989), J.A.Stackhouse, D.S.Kristol, S.Von Hagen and G.Rao.

Presentations

  • "An InVitro Cytotoxicity Study of Glutaraldehyde and No-ReactÒ Treated Bioprosthetic Heart Valves and the Aortic Wall", R. Ongosi, D.Kristol and S. Gabbay, presented at the 8th Annual Unitech Conference on Science and Technology, April 24, 1998.
  • "Computer Simulation of Cerebrovascualr Responses During Induction of Anesthesia: Comparison of Thiopental, Propofel and Etomidate", A. Mistry, H. Turndorf, S. Wolk, D.Kristol, A. Ritter and A. Bekker, presented at the 8th Annual Unitech Conference on Science and Technology, April 24, 1998.
  • "Computer Simulation of Cerebrovascualr Responses During Induced Hypotension", J. Schalago, S.Wolk, D.Kristol, A.Ritter, H. Turndorf and A. Bekker, presented at the 8th Annual Unitech Conference on Science and Technology, April 24, 1998.
  • "Effect of Electrostatic Interactions in Recognition of Acetylcholine by Acetylcholinesterase", C.Linaras, K.Singh, D.Kristol, and A.Ritter. presented at the 5th Conference on Current Trends in Computational Chemistry at Jackson State University, November 1-2, 1996.
  • "Comparative Study of the Protease Digestion of No-ReactTM Conventional Glutaraldehyde Treated Bioprosthetic Heart Valve"s, S.Yu, D.Kristol, A.Abolhoda, J.R.McCormick and S.Gabbay, presented at the 22nd Northeast Bioengineering Conference, March 15, 1996.
  • "Molecular Modeling Studies of AChE Inhibition by Sarin", C.E.Linaras, A.Ritter and D.S.Kristol, presented at the 22nd Northeast Bioengineering Conference, March 15, 1996.
  • "A Pharmacokinetic Model of the Liver", S.Patel, D.Kristol and A.Ritter, presented at the 21st Northeast Bioengineering Conference, May 22, 1995.
  • "Computer Simulation of Cerebrovascular Circulation and Assessment of Intracranial Hemodynamics During Induction of Anesthesia", S.Wolk, A.Bekker, A.Ritter and D.Kristol, presented at the 21st Northeast Bioengineering Conference, May 22, 1995.
  • "Molecular Modeling Studies on Acetylcholine-Acetylcholinesterase Interactions", L.Yadav, A.Ritter, and D.Kristol., presented at the 208th National Meeting of the American Chemical Society, August 24, 1994.
  • "Contour Extraction from HEVM Images of Microvessels Using Active Contour Models", M.Xiao, Y.Q.Shi, D.Kristol, L.Horn and P.Engler, presented at the 20th Northeast Bioengineering Conference, Springfield, MA, May 1994.
  • "Data Acquisition in the Viral Serology Laboratory for Clinical Decision Support in AIDS Research", T.J.Chahil, G.R.Rao, D.Kristol, R.J.Stephens, J.Swerdlow, A.J.Scolpino and T.N.Denny presented at the 20th Northeast Bioengineering Conference, Springfield, MA, May 1994.
  • "The Man-Machine Interaction in Central Nursing Stations", S.S.Kumar, H.Gage, D.Kristol and P.Engler, presented at the 20th Northeast Bioengineering Conference, Springfield, MA, May 1994.
  • "Identification of a Pharmacophore on H1 Histamine Receptor Antagonists: A Molecular Modeling Study", presented at the 15th International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego CA, October 28, 1993, N.Wokhlu, J.Yadav, A.Ritter, D. Kristol and S.Laxminaryan.
  • "A Multicompartment Model for Simulation of Soluble Gas Exchange in the Lungs", presented at the 19th Northeast Bioengineering Conference, March 18, 1993, A.Ritter, C.Varadhan and D.Kristol.
  • "The Thermal Model of the Rat Under Hemorrhagic Shock Hypothermia with Microwave Intervention", presented at the 19th Northeast Bioengineering Conference, March 19, 1993, L.Zhe, P.Engler and D.Kristol.
  • "Simulation of Intracranial Hemodynamics", presented at the 19th Northeast Bioengineering Conference, March 19, 1993, A.Ritter, G.Sundaram, D.Kristol and A.Bekker.
  • "A Computer Assisted Receptor Mapping Approach to the Design of Anti-AIDS Agents Directed at HIV Reverse Transcriptase", presented at the 19th Northeast Bioengineering Conference, March 19, 1993, M.Fisher, P.Yadav, J.Yadav, S.Laxminaryan, D.Kristol and M.Modak.
  • "Molecular Modeling of the Histamine H1 Receptor," 14th International Conference of the IEEE Engineering in Medicine and Biology Society, Paris, October 29, 1992, A.Ritter, C.Gerula, S.Laxminarayan, D.Kristol and J.Yadav.
  • "Steric Effects of Acyclic and Bridgehead Carbons Attached to Carbonyls," 14th International Conference of the IEEE Engineering in Medicine and Biology Society, Paris, October 29, 1992, D.Kristol, M.Fisher, J.Yadav, S.Laxminarayan and H.Perlmutter.
  • "Molecular Modeling of the Histamine H1 Receptor", 18th Northeast Bioengineering Conference, University of Rhode Island, March 13, 1992, C.Gerula, J.Yadav, D.Kristol and A.Ritter.
  • "A Model of Cardiovascular Function for the Regulation of Anaesthesia", 18th Northeast Bioengineering Conference, University of Rhode Island, March 13, 1992, B.Puranic, D.Kristol, A.Bekker and A.Ritter.
  • "Thrombus Formation and Blood Contacting Surface in Pneumatic Diaphragm Blood Pump," 16th Northeast Bioengineering Conference, Penn State University, March 26, 1990, H.S.Wang, D.S.Kristol and S.Gabbay.