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Department of Biomedical Engineering

Cho, Cheul H.

Contact Info
Title: Assistant Research Professor
Email: cho@njit.edu
Office: 204 York Center
Phone: 973-596-5381
Dept: Biomedical Engineering
Webpage: http://web.njit.edu/~cho

About Dr. Cho



Education

  • Postdoctoral Fellow, Harvard Medical School, Boston, MA, 2003-07 (Specialty: Stem Cell Bioengineering and Liver Tissue Engineering)
  • Ph.D. Chemical Engineering, Wayne State University, Detroit, Michigan, 2003(Specialty: Polymeric Biomaterials, Scaffold Tissue Engineering, and Stem Cell Bioengineering)Dissertation Title: A Three-dimensional Perfusion Bioreactor System with Porous Glycosaminoglycan-based Scaffolds for the Expansion of CD34+ Hematopoietic Stem Cells
  • M.S. Biomedical Engineering, University of Iowa, Iowa City, Iowa, 1992
  • B.S. Chemical Engineering, Dong-A University, Busan, South Korea, 1990

 

Professional Experience

  • Assistant Professor, Dept. of Biomedical Engineering, New Jersey Institute of Technology, Newark, 2007-present
  • Adjunct Assistant Professor, Dept. of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey (UMDNJ) - New Jersey Medical School, Newark, NJ, 2008-present
  • Research Fellow, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2003-2007
  • Research Assistant, Dept. of Chemical Engineering, Wayne State University, Detroit, Michigan, 1999-2003
  • Research Scientist, Biomedical Research Center, Korea Institute of Science & Technology (KIST), Seoul, Korea, 1997-98
  • Computer Administrator, Ministry of National Defense, Security Agency, Seoul, South Korea, 1994-1996 (served military duty)
  • Research Assistant, Dept. of Biomedical Engineering, University of Iowa, Iowa City, IA, 1991-1993

 

Reviewer for Journals

  • FASEB Journal
  • Tissue Engineering Journal
  • Journal of Biomedical Materials Research

Professional Activities/Organizations

  • BMES (Biomedical Engineering Society)
  • AIChE (American Institute of Chemical Engineer)
  • ISSCR (International Society for Stem Cell Research)

Courses Taught

  • Biological and Chemical Foundations of Biomedical Engineering
  • Cell and Biomaterial Engineering Laboratory
  • Research Skills in Stem Cell Tissue Engineering

 


Research Interests

 

  • Stem Cell Bioengineering and Regenerative Medicine
  • Multi-lineage Differentiation of Embryonic Stem Cells
  • Engineering 3-D Tissue Construct for Tissue Repair
  • In Vitro Co-Culture Models for Cell-Cell Interactions
  • Cell-Cell, Cell-ECM, Cell-Biomaterial Interactions
  • Cellular and Tissue Engineering (Liver, Cardiac, Neural)
  • Micropatterning of Cells and ECM for Cellular Interactions
  • Scaffold Tissue Engineering
  • Polymeric Biomaterials Design and Characterization
  • Liver Tissue Regeneration (In Vitro and In Vivo Models)

Research Opportunities

We welcome your interest and inquiries about Stem Cells and Tissue Engineering Lab. Research opportunities are available to students who are highly motivated and interested in doing research in the area of stem cell bioengineering, tissue engineering, and polymeric biomaterials. If you are interested in doing research in my lab, please contact me.


Selected Publications

·         Cheul H. Cho, Jae-Sung Park, Francois Berthiaume, Arno Tilles, Mehmet Toner, Martin Yarmush, “Layered Patterning of Hepatocytes in Coculture Systems Using Microfabricated Stencils", BioTechniques, Jan; 48: 47-52, 2010

·         Cheul H. Cho, Francois Berthiaume, Arno Tilles, Martin Yarmush, “A New Technique for Primary Hepatocyte Expansion In Vitro”, Biotechnology and Bioengineering, 2008, Oct;101 (2); 345-356

·         Daan van Poll, Biju Parekkadan, Cheul H. Cho, François Berthiaume, Arno W. Tilles, Yaakov Nahmias, Martin L. Yarmush, Mesenchymal Stem Cell-Derived Molecules Directly Modulate Hepatocellular Death and Regeneration In Vitro and In Vivo, Hepatology 2008, May;47(5): 1634-43 

·         Cheul H. Cho, Natesh Parashurama, Eric Y.H. Park, Kazuhiro Suganuma, Yaakov Nahmias, Jaesung Park, Arno W. Tilles, Francois Berthiaume, and Martin L. Yarmush, “Homogenous Differentiation of Hepatocyte-like Cells from Embryonic Stem Cells: Applications for the Treatment of Liver Failure”, FASEB Journal, 2008 Mar;22(3):898-909.

·         Natesh Parashurama, Koby Nahmias, Cheul H. Cho, Daan Poll, Arno W. Tilles, Francois Berthiaume, and Martin L. Yarmush, “Activin alters the kinetics of endoderm induction and in vivo differentiation in collagen gel cultures of embryonic stem cells”, Stem Cells, 2008 Feb; 26(2): 474-84.

·         Jae-Sung Park, Cheul H. Cho, Natesh Parashurama, Yawen Li, Francois Berthiaume, Arno Tilles, Mehmet Toner, Martin Yarmush, “Microfabrication-based Modulation of Embryonic Stem Cell Differentiation”, Lab on a Chip, 2007, 7, 1018-1028

·         Cheul H. Cho, Jaesung Park, Francois Berthiaume, Arno Tilles, Mehmet Toner, Martin Yarmush, “Oxygen Uptake Rates and Liver-Specific Functions of Hepatocyte and 3T3 Fibroblast Co-cultures”, Biotechnology and Bioengineering, 97 (1); 188-199, 2007 [Featured on the cover issue]

·         Cheul H. Cho, James F. Eliason and Howard WT Matthew, “Application of Porous Glycosaminoglycan-Based Scaffolds for Expansion of Human Cord Blood Stem Cells in Perfusion Culture”, Journal of Biomedical Materials Research Part A, 86A: 98-107, 2008

·         Howard Matthew, Cheul H. Cho, Ravi K Birla, Heather J Khanna, “Polysaccharides as Biomaterials”, IN: Biodegradable Polymers, Vol. 2, The Polymers in Biotechnology & Medicine (PMB) Series, Citus Books, London, Chapter 2; 35-68, 2003

·         M.J. Vonesh, C.H. Cho, J.V. Pinto, B.J. Kane, D.S. Lee, S.I. Roth, K.B. Chandran, D.D. McPherson, "Regional Vascular Mechanical Properties by 3-D Intravascular Ultrasound with Finite Element Analysis", American Journal of Physiology, 272 (Heart Circ. Physiol. 41): H425-H437, 1997

·         C.H. Cho, J.B. Choi, K. Choi, "Finite Element Analysis for the Contact Stress of Ultra-High Molecular Weight Polyethylene in Total Knee Arthroplasty”, Journal of Korea Society of Medical and Biological Engineering, Vol.20. No.1, 37-44, 1999

·         Y.K. Choi, C.H. Cho, J.B. Choi, K. Choi, “A Numerical Study on the Response of the Tibial Component in Total Knee Arthroplasty to Longitudinal Impact”, Journal of Korea Society of Medical and Biological Engineering, Vol. 19, No. 5, pp.503-511, 1998

SCI Impact Factors for Journals (2005 Thomson Scientific)

  • Hepatology (9.8), FASEB Journal (7.1), Stem Cells (6.1), Lab on a Chip (5.3), Biotechnology and Bioengineering (2.5), Journal of Biomedical Materials Research A (2.5), Tissue Engineering (2.9), American Journal of Physiology (3.6), BioTechniques (2.3)

 

Conference Abstracts /Presentations (Selected)

  • Cheul H. Cho, Natesh Parashurama, Eric Y.H. Park, Kazuhiro Suganuma, Yaakov Nahmias, Jaesung Park, Arno W. Tilles, Francois Berthiaume, and Martin L. Yarmush, “Directed Differentiation of Embryonic Stem Cells into Functional Hepatocyte-Like Cells: Applications for the Treatment of Liver Failure”, 2008 Annual Meeting of International Society for Stem Cell Research (ISSCR) Philadelphia, PA, June 11-14, 2008
  • Natesh Parashurama, Koby Nahmias, Cheul H. Cho, Daan Poll, Arno W. Tilles, Francois Berthiaume, and Martin L. Yarmush, “Activin alters the kinetics of endoderm induction and in vivo differentiation in collagen gel cultures of embryonic stem cells”, 2008 SBE’s International Conference on Stem Cell Engineering, Coronado, CA, Jan 20-23, 2008
  • Eric Y.H. Park, Cheul H. Cho, Arno W. Tilles, Martin L.Yarmush, “Engineering a stem cell niche to differentiate embryonic stem cells into functional hepatocytes”, 2007 Annual Meeting of Biomedical Engineering Society (BMES), Los Angeles, CA, 2007
  • Deepak Nagrath, Eric Y.H. Park, Cheul H. Cho, Marco Elchiver, Rongjun Zuo, Francois Berthiaume, Arno W. Tilles, Martin L.Yarmush.Maturation of Embyronic Stem Cells Into Hepatocytes Using Metabolic Flux Analysis, 2007 Annual Meeting of Biomedical Engineering Society (BMES), Los Angeles, CA, 2007
  • Eric Y.H. Park, Cheul H. Cho, Arno Tilles, Martin Yarmush, Derivation of Functional Hepatocytes from Murine Embryonic Stem Cells, Keystone Symposia, Tissue Engineering and Development Biology, Snowbird, Utah, April 12 - 17, 2007
  • Cheul H. Cho, Natesh Parashurama, Arno W. Tilles, Francois Berthiaume, and Martin L. Yarmush, Embryonic Stem Cell Differentiation into Early Endodermal and Hepatic Lineage Cells, 2006 Annual Methods in Bioengineering Conference, Cambridge, MA, July 17-18, 2006
  • Cheul H. Cho, Natesh Parashurama, Arno Tilles, Francois Berthiaume, Martin Yarmush, Embryonic Stem Cell Differentiation into Early Endodermal and Hepatic Lineage Cells, Second Annual Tony & Shelly Malkin Stem Cell Symposium, Harvard Club of Boston, MA, December 2, 2005
  • Cheul H. Cho, Natesh Parashurama, Arno Tilles, Francois Berthiaume, Martin Yarmush, Induction of Embryonic Stem Cells into Endoderm Hepatic Lineage Cells, 2005 Annual Meeting of AIChE (American Institute of Chemical Engineerers), Bioengineering Division, Cincinnati, OH, November, 2005
  • Cheul H. Cho, Jae-Sung Park, Francois Berthiaume, Arno Tilles, Mehmet Toner, Martin Yarmush, Application of Micropatterning Techniques to Co-Culture Systems for Hepatic Tissue Engineering, 2005 Annual Meeting of AIChE, Bioengineering Division, Cincinnati, OH, November, 2005
  • Cheul H. Cho, Francois Berthiaume, Arno Tilles, Martin Yarmush, Stimulation of adult rat hepatocyte proliferation in hepatocyte/3T3 fibroblast co-cultures, 2005 Annual Meeting of Biomedical Engineering Society (BMES), Tissue Engineering Session, Baltimore, MD, September, 2005
  • Cheul H. Cho, Jae S. Park, Francois Berthiaume, Arno Tilles, Mehmet Toner, Martin Yarmush, Oxygen consumption rates and liver-specific functions of hepatocyte/fibroblast co-cultures, 2005 Annual Meeting of Biomedical Engineering Society (BMES), Baltimore, MD, September, 2005
  • Cheul H. Cho, Jae S. Park, Francois Berthiaume, Arno Tilles, Mehmet Toner, Martin Yarmush, Oxygen consumption characteristics and liver specific functions of hepatocyte and fibroblast co-culture for bioartificial liver support design, 2005 Annual Meeting of American Chemical Society (ACS), Tissue Engineering Session, San Diego, CA, March, 2005
  • Cheul H. Cho, James F. Eliason and Howard WT Matthew, Porous Glycosaminoglycan-Based Scaffolds for Expansion of Hematopoietic Stem Cells in Perfusion Culture, 2004 World Congress of Biomaterials, Sydney, Australia, 2004
  • Cheul H. Cho, James F. Eliason and Howard WT Matthew, Application of Porous Glycosaminoglycan-Based Scaffolds for Expansion of Hematopoietic Stem Cells in Perfusion Culture, 2003 Annual Meeting of AIChE, Biomaterials Session, San Francisco, CA, November, 2003
  • Cheul H. Cho, James F. Eliason and Howard WT Matthew, In Vitro Expansion of CD34+ Cord Blood Stem Cells on Immobilized Glycosaminoglycans: Effects of Immobilized Method and Stem Cell Purity, 2002 Annual Meeting of AIChE, Bioengineering division, Indianapolis, IN, 2002
  • Cheul H. Cho and Howard WT Matthew, Ionic and Covalent Immobilization of Glycosaminoglycans on Chitosan Surfaces on the Expansion of CD34+ Blood Stem Cells, 2001 Annual Meeting of AIChE, Bioengineering division, Reno, Nevada, 2001
  • Cheul H. Cho, Sundararajan V. Madihally and Howard WT Matthew, Porous Chitosan-Glycosaminoglycan Microcarriers for Hematopoietic Perfusion Cultures: Optimization of Pore Microstructure, 1999 Annual Meeting of AIChE, Bioengineering division, Dallas, TX, 1999
  • J.B. Choi, C.H. Cho, Y.K. Cho, K. Choi, T.S. Lee, Static and Dynamic Analysis of the Tibial Components in Total Knee System, 3rd World Congress of Biomechanics, Sapporo, Japan, 1998