Murat Guvendiren, Ph.D.
Assistant Research Professor
New Jersey Center for Biomaterials
Designing Biomaterials for Tissue Engineering Applications and 3D Printing
The interaction of cells with a biomaterial is strongly regulated by the chemistry, mechanics, and topography of the biomaterial. Our ability to control these properties is crucial: 1) to develop model culture platforms to enhance our fundamental understanding of cellular function in vitro, and 2) to design scaffolds that enable functional integration in vivo. In particular, we are interested in hydrogels for soft-tissue engineering and solid scaffolds for hard-tissue engineering applications. In the first part of the seminar, we will focus on designing dynamic hydrogels with spatiotemporal control of mechanics and degradation in order to investigate cell-material interactions. Data will be presented on mechanics and how degradation controls stem cell fate decision in 2D vs. 3D culture. In the second part, we will focus on current efforts at the New Jersey Center for Biomaterials on designing novel biomaterial inks for 3D printing to fabricate solid scaffolds. Although 3D printing is a powerful technique to fabricate custom-designed and custom-fabricated devices, the lack of diversity in printable biomaterials is regarded as a bottleneck that limits the widespread use of 3D printing in medicine. We will present an overview of our current progress in developing novel biomaterial inks for 3D printing, and our efforts to create a toolbox of scaffolds with tunable architecture and curvature to control cellular function.